Description

8'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and isoquinoline fused-ring structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for synthesizing novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme function and biological mechanisms.
• Organic Synthesis Building Block: Utilized in complex multi-step organic syntheses due to its reactive bromine substituent and constrained spirocyclic geometry.
• Library Synthesis for High-Throughput Screening: Serves as a starting material for generating focused chemical libraries for biological screening.

Basic Information

Product Name	8'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]
CAS No.	885269-37-4
Molecular Formula	C12H12BrN
Molecular Weight	250.14 g/mol
Synonyms	8'-Bromo-1'H-spiro[cyclopropane-1,4'-isoquinoline]-2',3'-dihydro; 1'H-Spiro[cyclopropane-1,4'-isoquinoline], 8'-bromo-2',3'-dihydro-; 8-Bromo-2,3-dihydro-1H-spiro[cyclopropane-1,4-isoquinoline]; Spiro[cyclopropane-1,4'-isoquinoline], 8'-bromo-2',3'-dihydro-1'H-; 885269-37-4; 8'-Bromo-2',3'-dihydrospiro[cyclopropane-1,4'-isoquinoline]
EINECS	Contact for details

Quality Control

Our 8'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.