Description

7'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and brominated isoquinoline scaffold. This compound matters for its critical role in modern medicinal chemistry, serving as a versatile building block for the synthesis of novel drug candidates targeting central nervous system disorders and other therapeutic areas. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate to accelerate their discovery pipelines and develop next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel psychoactive substances and central nervous system (CNS) drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Organic Synthesis Building Block: The bromine atom and spirocyclic structure enable further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating complex molecular architectures.
• Ligand and Probe Development: Potential use in developing chemical probes for neurological target validation and biological pathway investigation.
• Fine Chemical Production: Serves as a specialized intermediate in the custom synthesis of high-value, low-volume chemicals for advanced applications.

Basic Information

Product Name	7'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]
CAS No.	885269-31-8
Molecular Formula	C₁₁H₁₀BrN
Molecular Weight	236.11 g/mol
Synonyms	7'-Bromo-1'H-spiro[cyclopropane-1,4'-isoquinoline]-2',3'-dihydro; 7-Bromospiro[cyclopropane-1,4'-isoquinoline]; 7'-Bromospiro[cyclopropane-1,4'-isoquinoline]; 7-Bromo-2,3-dihydro-1H-spiro[cyclopropane-1,4-isoquinoline]; 7-Bromo-1,2,3,4-tetrahydrospiro[isoquinoline-4,1'-cyclopropane]; Spiro[cyclopropane-1,4'-isoquinoline], 7'-bromo-2',3'-dihydro-1'H-; 885269-31-8
EINECS	Contact for details

Quality Control

Every batch of 7'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are developed to meet the stringent requirements of pharmaceutical R&D and are supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by NMR, IR, and/or MS), and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.