Description

6'-Methoxy-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] is a sophisticated spirocyclic organic compound featuring a fused isoquinoline and cyclopropane structure, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular architecture makes it a valuable building block for constructing complex pharmacophores and functional materials. This high-purity compound is essential for research and development in the pharmaceutical and agrochemical industries, particularly for medicinal chemists exploring novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially for central nervous system (CNS) targets, due to its privileged isoquinoline scaffold.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Development: Serves as an intermediate in creating novel active ingredients for crop protection products.
• Organic Synthesis: Employed in academic and industrial R&D for constructing complex spirocyclic and heterocyclic compounds.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein functions.
• Material Science: Investigated as a precursor for organic electronic materials and specialty polymers.

Basic Information

Product Name	6'-Methoxy-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]
CAS No.	885269-27-2
Molecular Formula	C₁₃H₁₅NO
Molecular Weight	201.27 g/mol
Synonyms	1'H-Spiro[cyclopropane-1,4'-isoquinoline], 2',3'-dihydro-6'-methoxy-; 6'-Methoxy-1'H-spiro[cyclopropane-1,4'-isoquinoline]-2',3'-dihydro; Spiro[cyclopropane-1,4'-isoquinoline], 2',3'-dihydro-6'-methoxy-; 6-Methoxyspiro[cyclopropane-1,1'(2'H)-isoquinoline]; 885269-27-2; 6'-Methoxy-2',3'-dihydrospiro[cyclopropane-1,4'-isoquinoline]
EINECS	Contact for details

Quality Control

Our 6'-Methoxy-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP standards for advanced intermediate production, ensuring suitability for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.