Description

5'-Chloro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] is a sophisticated spirocyclic organic building block of significant interest in advanced chemical synthesis. This compound matters for its unique structural framework, which incorporates a fused isoquinoline moiety with a cyclopropane ring, offering a rigid, three-dimensional scaffold for medicinal chemistry and materials science research. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used as a building block for developing new generation pesticides and herbicides with unique modes of action.
• Ligand & Catalyst Development: Employed in the design of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Acts as a monomer or additive in the research of advanced polymers with specific optical or electronic properties.
• Chemical Biology Probe: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting exploratory synthetic chemistry.

Basic Information

Product Name	5'-Chloro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]
CAS No.	885269-14-7
Molecular Formula	C12H12ClN
Molecular Weight	205.68 g/mol
Synonyms	1'H-Spiro[cyclopropane-1,4'-isoquinoline], 5'-chloro-2',3'-dihydro-; 5'-Chloro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-2',3'-dihydro; 5'-Chloro-2,3-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]; Spiro[cyclopropane-1,4'-isoquinoline], 5'-chloro-2',3'-dihydro-; 885269-14-7; 5-Chloro-2,3-dihydrospiro[cyclopropane-1,1'-isoquinoline]
EINECS	Contact for details

Quality Control

Our production of 5'-Chloro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.