Description

8'-Bromo-Spiro(Cyclopentane-1,4'-(3'H)-1',2',3',4'-Tetrahydroquinazoline)-2'-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic quinazolinone scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, especially within oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates with potential kinase inhibitory or receptor-modulating activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its complex, functionalized spirocyclic structure.
• Chemical Biology Probes: Serves as a core scaffold for developing molecular probes to study biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring specialized heterocyclic chemistry.
• Library Synthesis: A valuable reactant for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	8'-Bromo-Spiro(Cyclopentane-1,4'-(3'H)-1',2',3',4'-Tetrahydroquinazoline)-2'-One
CAS No.	885267-16-3
Molecular Formula	C13H13BrN2O
Molecular Weight	293.16 g/mol
Synonyms	8'-Bromospiro[cyclopentane-1,4'-(3'H)-quinazoline]-2'-one; 8'-Bromo-1,2,3,4-tetrahydrospiro[quinazoline-4,1'-cyclopentane]-2-one; 8'-Bromo-1,2,3,4-tetrahydrospiro[cyclopentane-1,4'-quinazolin]-2'(3'H)-one; 8'-Bromo-3'H-spiro[cyclopentane-1,4'-quinazoline]-2'-one; 8-Bromospiro(cyclopentane-1,4'-(3'H)-1',2',3',4'-tetrahydroquinazoline)-2'-one; CAS 885267-16-3
EINECS	Contact for details

Quality Control

Our 8'-Bromo-Spiro(Cyclopentane-1,4'-(3'H)-1',2',3',4'-Tetrahydroquinazoline)-2'-One is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.