Description

5-Bromo-3,3-Spiro(3-Tetrahydrofuran)-2,3-Dihydroindole is a high-value, complex heterocyclic building block featuring a unique spirocyclic architecture. This compound is essential for advanced organic synthesis, particularly in pharmaceutical research and development, where it serves as a critical precursor for creating novel molecular scaffolds. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of potential active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its complex structure for enhanced biological activity.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor for electron-transport or host materials in OLED displays and lighting due to its rigid, conjugated structure.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: Employed in university and CRO settings for methodological studies and the exploration of new chemical spaces in heterocyclic chemistry.
• Fine Chemical Synthesis: Acts as a starting material for the production of other high-value, specialty fine chemicals and dyes.

Basic Information

Product Name	5-Bromo-3,3-Spiro(3-Tetrahydrofuran)-2,3-Dihydroindole
CAS No.	885266-99-9
Molecular Formula	C12H12BrNO
Molecular Weight	266.14 g/mol
Synonyms	5-Bromo-2,3-dihydrospiro[indole-3,3'-oxolane]; 5-Bromo-3,3-spiro(tetrahydrofuran)indoline; 5-Bromospiro[indoline-3,3'-oxolane]; 5-Bromo-1,3-dihydrospiro[indene-2,3'-oxolane] (related structure); 885266-99-9; Spiro[oxolane-3,3'-indole], 5'-bromo-1',2'-dihydro-
EINECS	Contact for details

Quality Control

Our 5-Bromo-3,3-Spiro(3-Tetrahydrofuran)-2,3-Dihydroindole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.