Description

2-Bromo-5-Fluoro-4-Picoline is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for their synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging the fluorine and bromine substituents for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of functionalized heterocyclic compounds for electronic materials and organic semiconductors.
• Chemical Biology Probes: Utilized to create tagged or modified molecules for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom synthesis projects requiring specific halogenated pyridine motifs.

Basic Information

Product Name	2-Bromo-5-Fluoro-4-Picoline
CAS No.	885168-20-7
Molecular Formula	C6H5BrFN
Molecular Weight	190.01 g/mol
Synonyms	2-Bromo-5-fluoro-4-methylpyridine; 4-Methyl-2-bromo-5-fluoropyridine; 5-Fluoro-2-bromo-4-picoline; 2-Bromo-5-fluoro-4-picoline; 4-Picoline, 2-bromo-5-fluoro-; 5-Fluoro-2-bromo-4-methylpyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoro-4-Picoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.