Description

Methyl (2R)-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}Pent-4-Ynoate is a specialized, enantiomerically pure building block used in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of complex pharmaceutical molecules and bioactive compounds. It is primarily needed by research institutions and pharmaceutical companies engaged in peptide synthesis, medicinal chemistry, and the production of high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis, particularly for introducing chiral, alkyne-containing amino acid derivatives.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing molecular libraries in drug discovery and lead optimization programs.
• Bioconjugation: The alkyne functional group enables its use in click chemistry reactions for labeling and conjugating biomolecules.
• Chemical Biology Probes: Employed in the synthesis of probes for studying enzyme mechanisms and protein interactions.
• Asymmetric Synthesis: A valuable starting material for the preparation of other enantiomerically enriched compounds.

Basic Information

Product Name	Methyl (2R)-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}Pent-4-Ynoate
CAS No.	885104-38-1
Molecular Formula	C22H21NO4
Molecular Weight	363.41 g/mol
Synonyms	Fmoc-(R)-2-amino-pent-4-ynoic acid methyl ester; Methyl (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-ynoate; (R)-Methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-ynoate; Fmoc-D-Homopropargylglycine-OMe; Fmoc-D-Hpg-OMe; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]pent-4-ynoic acid methyl ester; Fmoc-D-2-amino-4-pentynoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (2R)-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}Pent-4-Ynoate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.