Description

Ethyl 2-(3-Bromophenyl)-2,2-Difluoroacetate is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique difluoroacetate ester group and bromophenyl moiety, which serve as versatile handles for further functionalization in complex molecule construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for introducing difluoroacetate and aryl bromide functionalities.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the difluoroacetate group can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or building block for synthesizing specialized polymers and liquid crystals with tailored electronic or optical properties.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on molecular conformation, reactivity, and lipophilicity in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and development-scale batches.

Basic Information

Product Name	Ethyl 2-(3-Bromophenyl)-2,2-Difluoroacetate
CAS No.	885068-75-7
Molecular Formula	C10H9BrF2O2
Molecular Weight	279.08 g/mol
Synonyms	2-(3-Bromophenyl)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl 3-Bromo-α,α-difluorobenzeneacetate; 3-Bromophenyl(difluoro)acetic Acid Ethyl Ester; Ethyl α,α-Difluoro-3-bromophenylacetate; Difluoro(3-bromophenyl)acetic Acid Ethyl Ester; (3-Bromophenyl)difluoroacetate Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(3-Bromophenyl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for full traceability and to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.