Description

R-3-Cbz-Amino Pyrrolidine-Hcl is a high-purity, protected pyrrolidine derivative widely used as a critical chiral building block in organic synthesis. This compound is essential for constructing complex molecular architectures, offering a versatile handle for peptide coupling and further functionalization. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and other bioactive molecules.

Application

• As a key chiral intermediate in the synthesis of pharmaceutical candidates and active pharmaceutical ingredients (APIs).
• Building block for the construction of peptidomimetics and constrained peptide analogs in medicinal chemistry.
• Starting material for the preparation of specialized ligands and catalysts in asymmetric synthesis.
• Intermediate in the research and development of protease inhibitors and other enzyme-targeted therapeutics.
• Used in the synthesis of complex natural products and other structurally sophisticated organic compounds.
• Valuable reagent in solid-phase peptide synthesis (SPPS) for introducing the Cbz-protected pyrrolidine scaffold.

Basic Information

Product Name	R-3-Cbz-Amino Pyrrolidine-Hcl
CAS No.	884653-79-6
Molecular Formula	C₁₃H₁₈N₂O₂•HCl
Molecular Weight	270.75 g/mol
Synonyms	(R)-1-[(Benzyloxy)carbonyl]-3-aminopyrrolidine hydrochloride; (R)-3-(Cbz-Amino)pyrrolidine hydrochloride; (R)-N-Cbz-3-Aminopyrrolidine HCl; (3R)-1-[(Phenylmethoxy)carbonyl]-3-pyrrolidinamine hydrochloride; (R)-3-Amino-1-(benzyloxycarbonyl)pyrrolidine hydrochloride; R-3-Cbz-NH-Pyrrolidine•HCl; (R)-Cbz-3-Amino-pyrrolidine hydrochloride salt
EINECS	Contact for details

Quality Control

Our R-3-Cbz-Amino Pyrrolidine-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided to guarantee consistent quality and batch-to-batch reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.