Description

6-(Tetrahydropyran-4-Yloxy)Nicotinonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular structure combining a nicotinonitrile core with a tetrahydropyranyloxy substituent. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates and novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Organic Synthesis: Serves as a versatile precursor for constructing more complex heterocyclic compounds in laboratory-scale and process chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	6-(Tetrahydropyran-4-Yloxy)Nicotinonitrile
CAS No.	884507-60-2
Molecular Formula	C11H12N2O2
Molecular Weight	204.23 g/mol
Synonyms	6-[(Oxan-4-yl)oxy]pyridine-3-carbonitrile; 6-(Tetrahydropyran-4-yloxy)-3-pyridinecarbonitrile; 3-Cyano-6-(tetrahydropyran-4-yloxy)pyridine; Nicotinonitrile, 6-(tetrahydro-2H-pyran-4-yloxy)-; 6-(Oxan-4-yloxy)nicotinonitrile; 6-(Tetrahydro-2H-pyran-4-yloxy)nicotinonitrile
EINECS	Contact for details

Quality Control

Our 6-(Tetrahydropyran-4-Yloxy)Nicotinonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term stability is required. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.