Description

5-Isocyanato-1-Methyl-1H-Indole is a versatile and reactive indole-based isocyanate building block. This compound is of significant value for its role as a key intermediate in the synthesis of complex heterocyclic molecules, particularly in pharmaceutical and advanced material research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active compounds and functional polymers.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel indole-containing drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides with specific biological activity.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating polyurethanes and other specialty polymers with unique thermal or mechanical properties.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes and affinity tags for studying enzyme function and protein interactions.
• Organic Synthesis Reagent: Utilized in academic and industrial R&D for constructing complex heterocyclic scaffolds via urea or carbamate formation.

Basic Information

Product Name	5-Isocyanato-1-Methyl-1H-Indole
CAS No.	884507-16-8
Molecular Formula	C10H8N2O
Molecular Weight	172.18 g/mol
Synonyms	1-Methyl-5-isocyanatoindole; 5-Isocyanato-1-methylindole; 1-Methyl-1H-indol-5-yl isocyanate; 1-Methylindole-5-isocyanate; 5-Isocyanato-1-methyl-1H-indole; 1-Methyl-5-isocyanato-1H-indole; Isocyanic acid, 1-methyl-1H-indol-5-yl ester
EINECS	Contact for details

Quality Control

Our 5-Isocyanato-1-Methyl-1H-Indole is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.