Description

3-Amino-2-Chloro-5-Fluoropyridine is a high-purity, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its unique halogenated and aminated pyridine structure makes it a critical intermediate for creating complex molecules with targeted biological activity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents enhance bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for developing functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic nitrogen heterocycle.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating molecular probes, enzyme inhibitors, and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	3-Amino-2-Chloro-5-Fluoropyridine
CAS No.	884495-37-8
Molecular Formula	C5H4ClFN2
Molecular Weight	146.55 g/mol
Synonyms	2-Chloro-5-fluoro-3-pyridinamine; 2-Chloro-5-fluoropyridin-3-amine; 3-Amino-2-chloro-5-fluoropyridine; 5-Fluoro-2-chloro-3-aminopyridine; 2-Chloro-5-fluoro-3-aminopyridine; 3-Pyridinamine, 2-chloro-5-fluoro-; 884495-37-8
EINECS	Contact for details

Quality Control

Our 3-Amino-2-Chloro-5-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.