Description

5-Chloro-2-Fluoro-3-Iodopyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by R&D chemists and process development scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Chemical Library Development: Utilized in medicinal chemistry for the parallel synthesis of diverse compound libraries for high-throughput screening.
• Ligand and Catalyst Preparation: Acts as a starting material for synthesizing novel nitrogen-containing ligands for transition metal catalysis.

Basic Information

Product Name	5-Chloro-2-Fluoro-3-Iodopyridine
CAS No.	884495-31-2
Molecular Formula	C5H2ClFIN
Molecular Weight	273.43 g/mol
Synonyms	3-Iodo-5-chloro-2-fluoropyridine; 2-Fluoro-3-iodo-5-chloropyridine; 5-Chloro-2-fluoro-3-iodopyridine; Pyridine, 5-chloro-2-fluoro-3-iodo-; 884495-31-2
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-3-Iodopyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.