Description

5-Bromo-2-(1,3-dioxolan-2-yl)pyridine is a versatile brominated heterocyclic building block featuring a protected aldehyde functionality. This compound is of significant value in organic synthesis, particularly in the construction of complex molecules for pharmaceutical and agrochemical research. It serves as a key intermediate for medicinal chemists and process development scientists engaged in cross-coupling reactions and the synthesis of novel active ingredients. The CAS number for this compound is 884495-16-3.

Application

This specialized pyridine derivative is primarily employed as a synthetic intermediate in advanced research and development. Its applications include:

• Pharmaceutical Intermediates: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen and heterocyclic structure.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and other advanced organic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	5-Bromo-2-(1,3-dioxolan-2-yl)pyridine
CAS No.	884495-16-3
Molecular Formula	C8H8BrNO2
Molecular Weight	230.06 g/mol
Synonyms	2-(5-Bromopyridin-2-yl)-1,3-dioxolane; 5-Bromo-2-(1,3-dioxolan-2-yl)pyridine; 2-(5-Bromo-2-pyridinyl)-1,3-dioxolane; 5-Bromo-2-pyridinecarboxaldehyde ethylene acetal; 884495-16-3; 5-Bromo-2-(1,3-dioxolan-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(1,3-dioxolan-2-yl)pyridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.