Description

2,5-Dichloro-3-Nitro-4-Picoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries that require precise chemical modification, such as medicinal chemistry for drug discovery and crop protection science for developing new active ingredients, are the primary users of this specialized material.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Serves as a key precursor in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Research: Used in the development of specialty chemicals, ligands for catalysis, and functionalized polymers requiring specific nitro- and chloro-substitution patterns.
• Dye and Pigment Intermediate: Employed in the synthesis of complex colorants and photographic chemicals due to its reactive nitro and chloro functional groups.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for creating complex biaryl structures.

Basic Information

Product Name	2,5-Dichloro-3-Nitro-4-Picoline
CAS No.	884495-05-0
Molecular Formula	C6H4Cl2N2O2
Molecular Weight	207.01 g/mol
Synonyms	4-Methyl-2,5-dichloro-3-nitropyridine; 3-Nitro-2,5-dichloro-4-picoline; 2,5-Dichloro-3-nitro-4-methylpyridine; 4-Picoline, 2,5-dichloro-3-nitro-; Pyridine, 2,5-dichloro-3-nitro-4-methyl-
EINECS	Contact for details

Quality Control

Our 2,5-Dichloro-3-Nitro-4-Picoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.