Description

4-Bromo-5-Fluoro-2-Methoxypyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the bromo and fluoro substituents enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or emissive compounds for OLEDs, due to its electron-deficient pyridine core.
• Chemical Biology Probes: Utilized to create tagged molecules or inhibitors for studying enzyme function and biological pathways in drug discovery.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-Bromo-5-Fluoro-2-Methoxypyridine
CAS No.	884495-00-5
Molecular Formula	C6H5BrFNO
Molecular Weight	206.01 g/mol
Synonyms	2-Methoxy-4-bromo-5-fluoropyridine; 5-Fluoro-4-bromo-2-methoxypyridine; 4-Bromo-5-fluoro-2-pyridinol methyl ether; 2-Pyridinol, 4-bromo-5-fluoro-, methyl ether; 884495-00-5 (CAS RN)
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Fluoro-2-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.