Description

3-Bromo-5-Chloro-2-Fluoropyridine is a high-value, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, leveraging the fluorine and halogen atoms for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromo and chloro substituents.
• Fluorine Chemistry: The fluorine atom provides a metabolic stability handle, making it valuable in medicinal chemistry for optimizing drug candidate pharmacokinetics.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and scale-up projects for client-specific molecules.

Basic Information

Product Name	3-Bromo-5-Chloro-2-Fluoropyridine
CAS No.	884494-87-5
Molecular Formula	C5H2BrClFN
Molecular Weight	210.43 g/mol
Synonyms	2-Fluoro-3-bromo-5-chloropyridine; 5-Chloro-3-bromo-2-fluoropyridine; 3-Bromo-5-chloro-2-fluoro-pyridine; Pyridine, 3-bromo-5-chloro-2-fluoro-; 2-Fluoropyridine, 3-bromo-5-chloro-
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Chloro-2-Fluoropyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.