Description

6-Chloro-3-Fluoro-2-(Hydroxymethyl)Pyridine is a high-value, multi-functional pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated structure, featuring both chloro and fluoro substituents alongside a hydroxymethyl group, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Precursor: The hydroxymethyl and halogen groups allow for functionalization to create novel ligands for metal catalysis or organocatalysts.
• Material Science Research: Employed in the synthesis of specialized polymers, liquid crystals, or organic electronic materials requiring halogenated pyridine cores.
• Custom Synthesis and Contract Manufacturing: Serves as a starting material for custom chemical synthesis services catering to specific client R&D projects.

Basic Information

Product Name	6-Chloro-3-Fluoro-2-(Hydroxymethyl)Pyridine
CAS No.	884494-80-8
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	2-(Hydroxymethyl)-6-chloro-3-fluoropyridine; 6-Chloro-3-fluoro-2-pyridinemethanol; (6-Chloro-3-fluoro-2-pyridinyl)methanol; 3-Fluoro-6-chloro-2-pyridinemethanol; 2-Pyridinemethanol, 6-chloro-3-fluoro-; 6-Chloro-3-fluoro-2-(hydroxymethyl)pyridine; 884494-80-8
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical intermediates. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, and every batch is analyzed to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles (typically by HPLC, GC, NMR) is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.