Description

6-(4-Methanesulfonylphenyl)-Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct biphenyl structure incorporating a nicotinic acid moiety and a methanesulfonyl group. This compound matters for its critical role as a key building block in the synthesis of novel, small-molecule therapeutic agents, particularly within kinase inhibitor research and development. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material to enable the efficient and scalable production of targeted drug candidates, ensuring precise molecular architecture for optimal bioactivity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of targeted kinase inhibitors and other biologically active molecules.
• Biochemical Research: Used as a reference standard or a probe compound in enzymatic assays and structure-activity relationship (SAR) studies.
• Organic Synthesis Building Block: Serves as a versatile scaffold for further chemical modifications, including amide coupling, esterification, and metal-catalyzed cross-coupling reactions.
• Drug Discovery & Development: Employed in medicinal chemistry programs for hit-to-lead optimization and the development of pre-clinical candidates.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects under cGMP or non-GMP conditions.
• Academic Research: Utilized in university and institutional labs for investigating new synthetic methodologies and pharmacological pathways.

Basic Information

Product Name	6-(4-Methanesulfonylphenyl)-Nicotinic Acid
CAS No.	884494-62-6
Molecular Formula	C13H11NO4S
Molecular Weight	277.30 g/mol
Synonyms	6-(4-Methanesulfonylphenyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-[4-(methylsulfonyl)phenyl]-; 6-(4-Methylsulfonylphenyl)nicotinic acid; 6-(p-Methanesulfonylphenyl)nicotinic Acid; 884494-62-6; 6-(4-Methanesulphonylphenyl)nicotinic acid; 6-(4-Methylsulfonylphenyl)-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-(4-Methanesulfonylphenyl)-Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing all test results are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.