Description

5-Chloro-2-Fluoronicotinic Acid is a high-purity, multifunctional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific halogenated motifs for enhanced bioactivity and material properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides with improved efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs).
• Chemical Biology Probes: Useful for designing molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Chloro-2-Fluoronicotinic Acid
CAS No.	884494-57-9
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.55 g/mol
Synonyms	2-Fluoro-5-chloronicotinic acid; 5-Chloro-2-fluoropyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-chloro-2-fluoro-; 5-Chloro-2-fluoro-3-pyridinecarboxylic acid; 884494-57-9; 2-Fluoro-5-chloro-3-pyridinecarboxylic acid; 5-Chloro-2-fluoro-nicotinic acid
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Fluoronicotinic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.