Description

2-Chloro-5-Fluoro-4-Formylpyridine is a high-value, multi-functional heterocyclic building block characterized by its reactive aldehyde group and halogen substituents. This compound is essential for facilitating efficient and precise molecular construction in advanced chemical synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The chloro and fluoro substituents make it a versatile substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-Chloro-5-Fluoro-4-Formylpyridine
CAS No.	884494-54-6
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	4-Formyl-2-chloro-5-fluoropyridine; 2-Chloro-5-fluoropyridine-4-carboxaldehyde; 5-Fluoro-2-chloroisonicotinaldehyde; 2-Chloro-5-fluoro-4-pyridinecarboxaldehyde; 884494-54-6; 2-Chloro-5-fluoro-4-pyridylcarboxaldehyde; 2-Chloro-5-fluoropyridine-4-carbaldehyde
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-4-Formylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.