Description

3-Bromo-2-Chloro-4-Iodopyridine is a highly functionalized halogenated pyridine derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique substitution pattern offers distinct reactivity for selective cross-coupling and nucleophilic substitution reactions, enabling the efficient construction of complex molecular architectures. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen handles for structure-activity relationship (SAR) studies.
• Material Science Building Block: Employed in the creation of functionalized ligands for catalysis, organic electronic materials, and liquid crystals.
• Cross-Coupling Reactions: The iodine and bromine substituents are excellent substrates for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl and heterobiaryl structures.
• Nucleophilic Aromatic Substitution: The chlorine atom at the 2-position is activated for displacement by various nucleophiles, allowing for further diversification of the pyridine core.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes and tags used in biochemical assays and diagnostic research.

Basic Information

Product Name	3-Bromo-2-Chloro-4-Iodopyridine
CAS No.	884494-53-5
Molecular Formula	C5H2BrClIN
Molecular Weight	318.34 g/mol
Synonyms	2-Chloro-3-bromo-4-iodopyridine; 4-Iodo-3-bromo-2-chloropyridine; 3-Bromo-2-chloro-4-iodopyridine; Pyridine, 3-bromo-2-chloro-4-iodo-; 884494-53-5
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Chloro-4-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.