Description

3-Bromo-2-Fluoro-4-Iodopyridine is a highly functionalized pyridine derivative that serves as a critical multi-halogenated building block in advanced organic synthesis. Its unique halogen pattern enables selective cross-coupling reactions, making it indispensable for constructing complex molecular architectures. This intermediate is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogen handles for structural diversification.
• Material Science Precursor: Employed in the creation of specialized ligands for catalysis and as a monomer for constructing functionalized polymers and liquid crystals.
• Cross-Coupling Reactions: Serves as a versatile substrate for Suzuki-Miyaura, Stille, and Negishi couplings due to the differential reactivity of its bromo and iodo substituents.
• Medicinal Chemistry Research: A valuable scaffold for generating compound libraries via parallel synthesis to explore structure-activity relationships (SAR).
• Chemical Biology Probes: Used to synthesize tagged molecules or affinity probes for target identification and binding studies.

Basic Information

Product Name	3-Bromo-2-Fluoro-4-Iodopyridine
CAS No.	884494-52-4
Molecular Formula	C5H2BrFIN
Molecular Weight	301.88 g/mol
Synonyms	3-Bromo-2-fluoro-4-iodopyridine; 4-Iodo-3-bromo-2-fluoropyridine; 2-Fluoro-3-bromo-4-iodopyridine; Pyridine, 3-bromo-2-fluoro-4-iodo-; 884494-52-4; 3-Br-2-F-4-I-pyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluoro-4-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.