Description

2-Fluoro-4-Iodonicotinic Acid is a halogenated nicotinic acid derivative that serves as a versatile and high-value synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both fluorine and iodine substituents, makes it a critical building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical developers engaged in the creation of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated and iodinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides where the halogen atoms enhance biological activity and environmental stability.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and material science applications.
• Chemical Biology Probes: Serves as a scaffold for creating molecular probes and diagnostic agents due to its modifiable carboxylic acid group and halogen handles.
• Advanced Material Development: A building block for organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl structures.

Basic Information

Product Name	2-Fluoro-4-Iodonicotinic Acid
CAS No.	884494-51-3
Molecular Formula	C6H3FINO2
Molecular Weight	266.99 g/mol
Synonyms	4-Iodo-2-fluoropyridine-5-carboxylic Acid; 2-Fluoro-4-iodopyridine-5-carboxylic Acid; 5-Carboxy-2-fluoro-4-iodopyridine; 2-Fluoro-4-iodo-3-pyridinecarboxylic Acid; 884494-51-3; 2-Fluoro-4-iodonicotinate
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Iodonicotinic Acid is manufactured and analyzed under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.