Description

2-Chloro-5-Fluoro-4-Iodo-3-Picoline is a high-value, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals, active pharmaceutical ingredients (APIs), and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a building block for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic substitution reactions to introduce complex halogenated pyridine motifs.
• R&D and Process Chemistry: Essential for route scouting, process optimization, and scale-up studies in fine chemical and contract manufacturing organizations (CMOs).

Basic Information

Product Name	2-Chloro-5-Fluoro-4-Iodo-3-Picoline
CAS No.	884494-50-2
Molecular Formula	C6H2ClFIN
Molecular Weight	271.44 g/mol
Synonyms	2-Chloro-5-fluoro-4-iodo-3-methylpyridine; 3-Picoline, 2-chloro-5-fluoro-4-iodo-; 4-Iodo-2-chloro-5-fluoro-3-methylpyridine; 2-Chloro-5-fluoro-4-iodo-3-methylpyridine; 2-Chloro-5-fluoro-4-iodo-3-picoline; 2-Chloro-5-fluoro-4-iodo-3-picoline (CAS 884494-50-2)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-4-Iodo-3-Picoline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles as verified by advanced analytical techniques including HPLC, GC-MS, and NMR. Our quality system is designed to support cGMP and ISO standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.