Description

3-Chloro-6-Fluoro-4-Iodo-2-Picoline is a highly functionalized pyridine derivative, a key halogenated building block prized for its versatility in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Chemical Library Development: A valuable scaffold for generating diverse compound libraries in high-throughput screening and drug discovery.

Basic Information

Product Name	3-Chloro-6-Fluoro-4-Iodo-2-Picoline
CAS No.	884494-47-7
Molecular Formula	C6H4ClFIN
Molecular Weight	271.46 g/mol
Synonyms	2-Picoline, 3-chloro-6-fluoro-4-iodo-; 3-Chloro-6-fluoro-4-iodo-2-methylpyridine; 4-Iodo-3-chloro-6-fluoro-2-methylpyridine; 2-Methyl-3-chloro-6-fluoro-4-iodopyridine; Halogenated Picoline Derivative; CAS 884494-47-7
EINECS	Contact for details

Quality Control

We supply 3-Chloro-6-Fluoro-4-Iodo-2-Picoline in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to strict internal quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.