Description

2-Chloro-5-Fluoro-3-Hydroxypyridine CAS NO 884494-35-3 is a high-purity halogenated pyridine derivative that serves as a critical pharmaceutical intermediate and organic building block. Its unique substitution pattern makes it a valuable scaffold for synthesizing complex molecules, particularly in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders and anti-infectives.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions in fine chemical production.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers and electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.
• Custom Synthesis and Contract Manufacturing: A starting material for bespoke chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Item	Detail
Product Name	2-Chloro-5-Fluoro-3-Hydroxypyridine
CAS No.	884494-35-3
Molecular Formula	C5H3ClFNO
Molecular Weight	147.54 g/mol
Synonyms	3-Hydroxy-2-chloro-5-fluoropyridine; 2-Chloro-5-fluoro-3-pyridinol; 5-Fluoro-2-chloro-3-hydroxypyridine; 2-Chloro-5-fluoro-3-pyridinone (tautomer); 2-Chloro-5-fluoro-3(1H)-pyridinone; 3-Pyridinol, 2-chloro-5-fluoro-; 884494-35-3; 2-Cl-5-F-3-OH-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Fluoro-3-Hydroxypyridine is manufactured under a strict quality management system. Our products undergo rigorous analytical testing to ensure they meet the high-purity standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.