Description

(S)-tert-Butyl 4-Cyanothiazolidine-3-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry and drug discovery. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce a functionalized thiazolidine scaffold with a protected amine and nitrile group.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor research.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to explore new therapeutic candidates.
• Peptidomimetics Synthesis: Serves as a constrained scaffold for creating peptide mimics with enhanced metabolic stability and bioavailability.
• Agrochemical Research: Employed as a building block for developing new crop protection agents and pesticides.
• Chemical Biology: Useful as a probe or linker in bioconjugation and the study of biological pathways.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecular architectures.

Basic Information

Product Name	(S)-tert-Butyl 4-Cyanothiazolidine-3-Carboxylate
CAS No.	884006-57-9
Molecular Formula	C9H14N2O2S
Molecular Weight	214.28 g/mol
Synonyms	(S)-tert-Butyl 4-cyano-1,3-thiazolidine-3-carboxylate; 3-Thiazolidinecarboxylic acid, 4-cyano-, 1,1-dimethylethyl ester, (4S)-; (4S)-4-Cyano-1,3-thiazolidine-3-carboxylic acid tert-butyl ester; tert-Butyl (4S)-4-cyano-1,3-thiazolidine-3-carboxylate; (S)-4-Cyano-thiazolidine-3-carboxylic acid tert-butyl ester; BOC-Thz(CN)-OH (tert-butyl ester); (S)-Boc-4-cyano-thiazolidine-3-carboxylate
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 4-Cyanothiazolidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade standards for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.