Description

2-Amino-3,5-difluoro-4-(trifluoromethyl)pyridine is a high-value, multi-fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both amino and trifluoromethyl substituents on a difluoropyridine core, makes it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and material science applications.
• Fluorinated Liquid Crystal Research: Employed in the development of fluorinated components for electronic display materials.
• Organic Electronic Materials: Acts as a building block for electron-deficient units in organic semiconductors and other advanced materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthetic projects requiring fluorinated pyridine chemistry.

Basic Information

Product Name	2-Amino-3,5-difluoro-4-(trifluoromethyl)pyridine
CAS No.	883498-68-8
Molecular Formula	C7H3F5N2
Molecular Weight	210.10 g/mol
Synonyms	4-(Trifluoromethyl)-3,5-difluoropyridin-2-amine; 3,5-Difluoro-4-(trifluoromethyl)pyridin-2-amine; 2-Amino-3,5-difluoro-4-trifluoromethylpyridine; 2-Pyridinamine, 3,5-difluoro-4-(trifluoromethyl)-; 883498-68-8
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-3,5-difluoro-4-(trifluoromethyl)pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.