Description

3-Pyridinecarboxamide, n-Hydroxy-6-(Trifluoromethyl)- is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a hydroxamic acid moiety and a trifluoromethyl group, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily targeted at R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine chemistry for enhanced bioactivity and metabolic stability. We supply this material with a focus on high purity, batch-to-batch consistency, and reliable global logistics to support your complex synthesis workflows.

Application

• Pharmaceutical Intermediate: Key synthon for the development of enzyme inhibitors, particularly targeting metalloenzymes like histone deacetylases (HDACs).
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Chemical Biology Probe Development: Serves as a precursor for creating molecular probes to study protein function and cellular pathways.
• Material Science: Potential intermediate for synthesizing functionalized ligands used in catalysis and advanced polymeric materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-specific projects requiring fluorinated pyridine scaffolds.

Basic Information

Product Name	3-Pyridinecarboxamide, n-Hydroxy-6-(Trifluoromethyl)-
CAS No.	883498-28-0
Molecular Formula	C7H5F3N2O2
Molecular Weight	206.12 g/mol
Synonyms	N-Hydroxy-6-(trifluoromethyl)nicotinamide; 6-(Trifluoromethyl)pyridine-3-carbohydroxamic acid; 6-(Trifluoromethyl)nicotinohydroxamic acid; 3-Carbamoyl-N-hydroxypyridine-6-trifluoromethyl; 6-Trifluoromethyl-3-pyridinecarbohydroxamic acid; N-Hydroxy-6-trifluoromethylnicotinamide; 6-(Trifluoromethyl)pyridine-3-carboxylic acid hydroxamide
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinecarboxamide, n-Hydroxy-6-(Trifluoromethyl)- is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and MS, to ensure compliance with industry standards and customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture and oxidation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.