Description

Norvaline, n-Acetyl-2-Hydroxy-, Methyl Ester is a specialized chiral building block and protected amino acid derivative. This compound is of significant value in advanced organic synthesis and pharmaceutical research, particularly for the construction of complex peptide mimetics and bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics to enhance metabolic stability and bioavailability of drug candidates.
• Protease Inhibitor Development: Serves as a core structural component in the development of enzyme inhibitors targeting proteases.
• Chemical Biology Probes: Employed in the creation of labeled or modified amino acids for studying protein function and interactions.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in stereoselective synthesis to introduce specific chiral centers.
• Academic & Institutional Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Norvaline, n-Acetyl-2-Hydroxy-, Methyl Ester
CAS No.	883456-90-4
Molecular Formula	C8H15NO4
Molecular Weight	189.21 g/mol
Synonyms	Methyl 2-(Acetylamino)-2-hydroxy-4-methylpentanoate; 2-(Acetylamino)-2-hydroxy-4-methylpentanoic Acid Methyl Ester; 2-Acetamido-2-hydroxy-4-methylpentanoic Acid Methyl Ester; N-Acetyl-2-hydroxy-norvaline Methyl Ester; (2R/S)-2-(Acetylamino)-2-hydroxy-4-methylpentanoic Acid Methyl Ester; Methyl N-Acetyl-2-hydroxynorvalinate; Ac-Hyl(Me)-OMe (common peptide notation); A building block for peptidomimetics.
EINECS	Contact for details

Quality Control

Our Norvaline, n-Acetyl-2-Hydroxy-, Methyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (if applicable), and impurity profiles. We support cGMP compliance for advanced applications and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.