Description

3-Chloro-n-Hydroxy-5-(Trifluoromethyl)-2-Pyridinecarboxamide is a specialized pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its unique trifluoromethyl and hydroxamic acid functional groups, which are essential for modulating the biological activity and physicochemical properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly protease inhibitors and other enzyme-targeting therapeutics.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, especially protease inhibitors (e.g., MMP, HDAC inhibitors) and anti-inflammatory agents.
• Agrochemical Research: Used in the synthesis of advanced herbicides and fungicides, leveraging the trifluoromethyl group for enhanced bioavailability and stability.
• Chemical Biology Probe: Serves as a precursor for activity-based probes (ABPs) to study enzyme function and inhibition mechanisms in biological systems.
• Metal Chelation Studies: The hydroxamic acid moiety makes it valuable for research into metal ion chelation and sequestration applications.
• Material Science Precursor: Potential building block for functionalized polymers or ligands in catalytic systems.

Basic Information

Product Name	3-Chloro-n-Hydroxy-5-(Trifluoromethyl)-2-Pyridinecarboxamide
CAS No.	882293-62-1
Molecular Formula	C7H4ClF3N2O2
Molecular Weight	240.57 g/mol
Synonyms	3-Chloro-5-(trifluoromethyl)picolinohydroxamic acid; 3-Chloro-5-(trifluoromethyl)pyridine-2-carbohydroxamic acid; 2-Pyridinecarboxamide, 3-chloro-N-hydroxy-5-(trifluoromethyl)-; 3-Chloro-N-hydroxy-5-(trifluoromethyl)picolinamide; 3-Chloro-5-trifluoromethylpyridine-2-hydroxamic acid; Picolinohydroxamic acid, 3-chloro-5-(trifluoromethyl)-; CAS 882293-62-1
EINECS	Contact for details

Quality Control

Our 3-Chloro-n-Hydroxy-5-(Trifluoromethyl)-2-Pyridinecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.