Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-5-Fluoro-1-[(4-Methylphenyl)Sulfonyl]- is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated and sulfonated heterocyclic structure. This compound is of significant value in medicinal chemistry for constructing complex molecular scaffolds, enabling the development of targeted therapeutics. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted small-molecule therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and development projects.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-5-Fluoro-1-[(4-Methylphenyl)Sulfonyl]-
CAS No.	882033-67-2
Molecular Formula	C14H10ClFN2O2S
Molecular Weight	324.76 g/mol
Synonyms	4-Chloro-5-fluoro-1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-fluoro-1-(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine; 1-(4-Methylbenzenesulfonyl)-4-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridine; 882033-67-2; 4-Chloro-5-fluoro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-5-Fluoro-1-[(4-Methylphenyl)Sulfonyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.