Description

2-Chloro-5-Fluoro-4-Methyl-Pyridine is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a versatile and valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where its halogenated pyridine core contributes to biological activity.
• Material Science Research: Employed as a precursor for creating functionalized ligands, organic electronic materials, and liquid crystals.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects requiring specific halogenated heterocycles.

Basic Information

Product Name	2-Chloro-5-Fluoro-4-Methyl-Pyridine
CAS No.	881891-83-4
Molecular Formula	C6H5ClFN
Molecular Weight	145.56 g/mol
Synonyms	4-Methyl-2-chloro-5-fluoropyridine; 5-Fluoro-2-chloro-4-methylpyridine; 2-Chloro-5-fluoro-4-picoline; 881891-83-4; 4-Methyl-5-fluoro-2-chloropyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-4-Methyl-Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.