Description

3-Carboxymethoxy-Piperidine-1-Carboxylic Acid Benzyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is essential for research and development chemists, process scale-up engineers, and manufacturers within the global pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for novel drug development.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disorder research.
• Peptidomimetic Chemistry: Used to introduce constrained piperidine scaffolds and protected carboxylic acid functionalities into peptide-like molecules to enhance stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• API Process Development: Employed in the optimization and scale-up of synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract manufacturing organizations (CMOs) serving the pharmaceutical sector.

Basic Information

Product Name	3-Carboxymethoxy-Piperidine-1-Carboxylic Acid Benzyl Ester
CAS No.	881656-67-3
Molecular Formula	C15H19NO5
Molecular Weight	293.31 g/mol
Synonyms	1-(Benzyloxycarbonyl)-3-(carboxymethoxy)piperidine; Benzyl 3-(carboxymethoxy)piperidine-1-carboxylate; 3-(Carboxymethoxy)-1-piperidinecarboxylic Acid Benzyl Ester; 1-CBZ-3-Carboxymethoxypiperidine; N-CBZ-3-(Carboxymethoxy)piperidine; Piperidine-1-carboxylic acid, 3-(carboxymethoxy)-, benzyl ester; 881656-67-3
EINECS	Contact for details

Quality Control

Our 3-Carboxymethoxy-Piperidine-1-Carboxylic Acid Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.