Description

6-Cyclopropyl-3-Methyl-1-Phenyl-1H-Pyrazolo-[3,4-B]Pyridine-4-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the research and synthesis of novel drug candidates, particularly those targeting kinase inhibition and other enzyme-related pathways.
• Chemical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in academic and industrial R&D labs.
• Process Chemistry Development: Employed in scaling up synthetic routes and optimizing manufacturing processes for potential new chemical entities (NCEs).
• Biochemical Tool Compound: Utilized in biological assays and screening libraries to investigate specific biological targets and mechanisms of action.

Basic Information

Product Name	6-Cyclopropyl-3-Methyl-1-Phenyl-1H-Pyrazolo-[3,4-B]Pyridine-4-Carboxylic Acid Hydrochloride
CAS No.	881443-44-3
Molecular Formula	C₁₈H₁₆ClN₃O₂
Molecular Weight	341.79 g/mol
Synonyms	6-Cyclopropyl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid hydrochloride; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 6-cyclopropyl-3-methyl-1-phenyl-, hydrochloride; 881443-44-3; Pyrazolopyridine-4-carboxylic acid derivative; Cyclopropyl-pyrazolopyridinecarboxylic acid HCl salt
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets exacting specifications for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.