Description

5-(2,2,2-Trifluoroethoxy)Pyridine-2-Carboxylic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring a trifluoroethoxy side chain, makes it an essential intermediate for developing advanced materials and active pharmaceutical ingredients (APIs). This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine moiety can improve biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals, contributing to materials with unique thermal and optical properties.
• Chemical Biology Probes: Useful for designing fluorinated probes and tags for studying biological systems and mechanisms.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-(2,2,2-Trifluoroethoxy)Pyridine-2-Carboxylic Acid
CAS No.	881409-53-6
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	2-Pyridinecarboxylic acid, 5-(2,2,2-trifluoroethoxy)-; 5-(Trifluoroethoxy)picolinic acid; 5-(2,2,2-Trifluoroethoxy)-2-pyridinecarboxylic acid; 5-(Trifluoroethoxy)pyridine-2-carboxylic acid; 881409-53-6; Picolinic acid, 5-(trifluoroethoxy)-; 5-(TFEO)Pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-(2,2,2-Trifluoroethoxy)Pyridine-2-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.