Description

n-(4-[(-3-Chloro-4-Fluorophenyl)Amino]Pyrido[3,4-D]Pyrimidin-6-Yl-2-Butynamide is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is valued for its role as a key synthetic building block in the development of targeted kinase inhibitors and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology and signal transduction pathway research.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors.
• Biochemical Research: Used as a reference standard and active probe in enzymatic assays and cellular studies to investigate specific biological pathways.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemistry programs aimed at optimizing potency, selectivity, and pharmacokinetic properties.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic synthesis and chemical biology.
• Contract Research Organizations (CROs): Supplied to CROs supporting pre-clinical development and analytical method development for client projects.

Basic Information

Product Name	n-(4-[(-3-Chloro-4-Fluorophenyl)Amino]Pyrido[3,4-D]Pyrimidin-6-Yl-2-Butynamide
CAS No.	881001-19-0
Molecular Formula	C21H14ClFN6O
Molecular Weight	420.82 g/mol
Synonyms	N-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)but-2-ynamide; 2-Butynamide, N-[4-[[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-; 881001-19-0; UNII-9J8K2A6U4Q; 9J8K2A6U4Q; Pyrido[3,4-d]pyrimidine derivative; Kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our n-(4-[(-3-Chloro-4-Fluorophenyl)Amino]Pyrido[3,4-D]Pyrimidin-6-Yl-2-Butynamide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.