Description

2-((tert-Butyldimethylsilyloxy)Methyl) Pyridine-4-Boronic Acid Pinacol Ester is a high-value, protected boronic ester derivative, a crucial advanced intermediate in modern synthetic chemistry. Its core value lies in enabling complex cross-coupling reactions, particularly Suzuki-Miyaura couplings, while offering enhanced stability and solubility for sophisticated molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules. CAS No. 880495-84-1.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug candidates, especially those containing pyridine and biaryl motifs via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and functional polymers.
• Chemical Biology & Probe Development: Employed in synthesizing molecular probes and bioconjugates for studying biological systems.
• Academic & Process R&D: A valuable reagent for methodological development in organic synthesis and scaling up synthetic routes in process chemistry.

Basic Information

Product Name	2-((tert-Butyldimethylsilyloxy)Methyl) Pyridine-4-Boronic Acid Pinacol Ester
CAS No.	880495-84-1
Molecular Formula	C₁₈H₃₂BNO₃Si
Molecular Weight	349.36 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(((tert-butyldimethylsilyl)oxy)methyl)pyridine; 2-(((tert-Butyldimethylsilyl)oxy)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Pyridineboronic acid, 2-(((1,1-dimethylethyl)dimethylsilyl)oxy)methyl]-, 1,3,2-dioxaborolane ester; TBDMS-protected pyridine-4-boronic acid pinacol ester; 4-Borono-2-((tert-butyldimethylsilyloxy)methyl)pyridine pinacol ester
EINECS	Contact for details

Quality Control

Our 2-((tert-Butyldimethylsilyloxy)Methyl) Pyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.