Description

8-Amino-2-Azaspiro[4.5]Decan-3-One is a high-value, nitrogen-containing spirocyclic building block with significant synthetic utility. This compound is prized for its rigid, three-dimensional structure, which is crucial for modulating the physicochemical properties and biological activity of advanced molecules. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients. Its unique scaffold is instrumental in creating compounds with enhanced selectivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of new drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Development: Used in creating novel pesticides and herbicides, where the spirocyclic structure can contribute to improved efficacy and environmental profile.
• Chemical Biology Probe Synthesis: Employed in constructing molecular probes for studying enzyme function and biological pathways.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific thermal or mechanical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	8-Amino-2-Azaspiro[4.5]Decan-3-One
CAS No.	880271-29-4
Molecular Formula	C9H16N2O
Molecular Weight	168.24 g/mol
Synonyms	8-Amino-2-azaspiro[4.5]decan-3-one; 2-Azaspiro[4.5]decan-3-one, 8-amino-; 880271-29-4; 8-Amino-2-azaspiro[4.5]decan-3-one; 8-Amino-2-azaspiro[4.5]decan-3-one; 8-Amino-2-azaspiro[4.5]decan-3-one; 8-Amino-2-azaspiro[4.5]decan-3-one; 8-Amino-2-azaspiro[4.5]decan-3-one
EINECS	Contact for details

Quality Control

Our 8-Amino-2-Azaspiro[4.5]Decan-3-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and cGMP (current Good Manufacturing Practice) intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.