Description

(4S,5R)-Ethyl 5-((R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)-4-Methyl-1,3,2-Dioxathiolane-4-Carboxylate 2,2-Dioxide is a high-purity, advanced chiral intermediate characterized by its complex stereochemistry and protected functional groups. This compound is of critical importance for the synthesis of complex bioactive molecules, offering precise stereochemical control in multi-step organic reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex, stereochemically defined active pharmaceutical ingredients (APIs).
• Antiviral Drug Development: Used in research and production pathways for nucleoside/nucleotide analogs and protease inhibitors.
• Anticancer Agent Synthesis: Serves as a precursor in the construction of novel chemotherapeutic compounds.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce specific stereocenters.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial manufacturing of fine chemicals.
• Academic & Industrial Research: A valuable reagent for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(4S,5R)-Ethyl 5-((R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)-4-Methyl-1,3,2-Dioxathiolane-4-Carboxylate 2,2-Dioxide
CAS No.	879551-01-6
Molecular Formula	C₁₂H₂₀O₈S
Molecular Weight	324.35 g/mol
Synonyms	Ethyl (4S,5R)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide; (4S,5R)-Ethyl 5-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-4-methyl-1,3,2-dioxathiolane-4-carboxylate S,S-dioxide; 1,3,2-Dioxathiolane-4-carboxylic acid, 5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-methyl-, ethyl ester, 2,2-dioxide, (4S,5R)-; Advanced Chiral Sulfate Ester Intermediate; Protected Diol Sulfate Derivative.
EINECS	Contact for details

Quality Control

Our (4S,5R)-Ethyl 5-((R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)-4-Methyl-1,3,2-Dioxathiolane-4-Carboxylate 2,2-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.