Description

8-(Nitromethyl)-1,4-Dioxaspiro[4.5]Decan-8-Ol is a versatile and high-value nitro-functionalized spirocyclic compound, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both a protected ketone and a reactive nitroalkanol group, makes it indispensable for constructing complex molecular architectures with precise stereochemistry. This intermediate is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly in routes requiring spirocyclic or nitro-containing scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific stereochemistry impacts biological activity.
• Asymmetric Catalysis: Employed as a precursor or ligand in catalytic systems due to its rigid, chiral dioxolane ring structure.
• Fine Chemical Production: Serves as a building block for specialty chemicals, flavors, fragrances, and advanced polymers.
• Academic & Industrial R&D: A valuable compound for methodological development in organic chemistry, including studies on nitroaldol (Henry) reactions and spirocycle formation.
• Material Science: Potential intermediate in the synthesis of novel organic frameworks or functional materials with specific optical or electronic properties.

Basic Information

Product Name	8-(Nitromethyl)-1,4-Dioxaspiro[4.5]Decan-8-Ol
CAS No.	879514-21-3
Molecular Formula	C10H17NO5
Molecular Weight	231.25 g/mol
Synonyms	8-(Nitromethyl)-1,4-dioxaspiro[4.5]decan-8-ol; 1,4-Dioxaspiro[4.5]decan-8-ol, 8-(nitromethyl)-; 8-Hydroxy-8-(nitromethyl)-1,4-dioxaspiro[4.5]decane; Nitromethyl Spiroketal Alcohol; (8-Hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)nitromethane
EINECS	Contact for details

Quality Control

Our production of 8-(Nitromethyl)-1,4-Dioxaspiro[4.5]Decan-8-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and commercial use. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.