Description

5-Nitro-1'-((2-(Trimethylsilyl)Ethoxy)Methyl)-1,3-Dihydrospiro[Indene-2,3'-Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One is a sophisticated spirocyclic organic compound that serves as a critical advanced intermediate in modern pharmaceutical research and development. Its complex molecular architecture, featuring a nitro group and a protected heterocyclic system, makes it invaluable for constructing novel bioactive molecules. This high-purity intermediate is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological screening against novel targets.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific enzyme functions or biological pathways.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs engaged in custom synthesis and development services for clients.

Basic Information

Product Name	5-Nitro-1'-((2-(Trimethylsilyl)Ethoxy)Methyl)-1,3-Dihydrospiro[Indene-2,3'-Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One
CAS No.	879132-49-7
Molecular Formula	C22H27N3O4Si
Molecular Weight	425.56 g/mol
Synonyms	5-Nitro-1'-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; 1,3-Dihydro-5-nitro-1'-[[2-(trimethylsilyl)ethoxy]methyl]spiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; 879132-49-7; Spiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one, 1,3-dihydro-5-nitro-1'-((2-(trimethylsilyl)ethoxy)methyl)-; 5-Nitro-1'-SEM-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; 1'-((2-(Trimethylsilyl)ethoxy)methyl)-5-nitro-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
EINECS	Contact for details

Quality Control

Our 5-Nitro-1'-((2-(Trimethylsilyl)Ethoxy)Methyl)-1,3-Dihydrospiro[Indene-2,3'-Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.