Description

(E)-3-(Dimethylamino)-1-(3-Imidazo[1,2-A]Pyridyl)-2-Propen-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique enone structure linked to an imidazopyridine moiety. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for synthesizing novel bioactive molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the development of fluorescent or affinity-based probes to study biological pathways and target engagement.
• Organic Synthesis Building Block: Utilized in multi-step synthetic routes to construct complex heterocyclic systems due to its reactive α,β-unsaturated ketone functionality.
• Academic & Contract Research: Serves as a valuable reagent for universities and CROs (Contract Research Organizations) conducting cutting-edge chemical research.

Basic Information

Product Name	(E)-3-(Dimethylamino)-1-(3-Imidazo[1,2-A]Pyridyl)-2-Propen-1-One
CAS No.	878804-63-8
Molecular Formula	C₁₂H₁₃N₃O
Molecular Weight	215.25 g/mol
Synonyms	(E)-3-(Dimethylamino)-1-(imidazo[1,2-a]pyridin-3-yl)prop-2-en-1-one; 1-(Imidazo[1,2-a]pyridin-3-yl)-3-(dimethylamino)-2-propen-1-one; 3-(Dimethylamino)-1-(imidazo[1,2-a]pyridin-3-yl)-2-propen-1-one; (E)-3-(Dimethylamino)-1-(3-imidazo[1,2-a]pyridinyl)-2-propen-1-one; Imidazo[1,2-a]pyridine-3-propenone derivative; CAS 878804-63-8
EINECS	Contact for details

Quality Control

Our (E)-3-(Dimethylamino)-1-(3-Imidazo[1,2-A]Pyridyl)-2-Propen-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.