Description

Methyl 3-(Bromomethyl)-4-Fluorobenzoate is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters because its unique combination of a reactive bromomethyl group and a fluorine substituent makes it a versatile precursor for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens used in display technologies.
• Cross-Coupling Reactions: The bromomethyl group facilitates Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Functional Material Research: Employed in the synthesis of fluorinated organic semiconductors and polymers for electronic applications.
• Derivatization Agent: Used to introduce the 3-(bromomethyl)-4-fluorobenzoate moiety into larger molecular scaffolds for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Methyl 3-(Bromomethyl)-4-Fluorobenzoate
CAS No.	878744-25-3
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	4-Fluoro-3-(bromomethyl)benzoic acid methyl ester; Methyl 4-fluoro-3-(bromomethyl)benzoate; 3-Bromomethyl-4-fluorobenzoic acid methyl ester; Benzoic acid, 3-(bromomethyl)-4-fluoro-, methyl ester; Methyl 3-bromomethyl-4-fluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 3-(Bromomethyl)-4-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency for research and development applications. Certificates of Analysis (COA) with full characterization data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.