Description

3-Methyl-6-[2-(Trifluoromethyl)Phenyl]Isoxazolo[5,4-B]Pyridine-4-Carboxylic Acid is a high-value, heterocyclic carboxylic acid derivative featuring a fused isoxazolopyridine core and a trifluoromethylphenyl substituent. This compound is a critical pharmaceutical intermediate and advanced building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique trifluoromethyl and fused heterocyclic structure, which can enhance metabolic stability and binding affinity.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, or insecticides, leveraging the biological activity of the isoxazole and pyridine motifs.
• Chemical Biology Probe: Acts as a scaffold for creating tool compounds to study biological pathways and protein functions.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials due to its rigid, aromatic structure.

Basic Information

Product Name	3-Methyl-6-[2-(Trifluoromethyl)Phenyl]Isoxazolo[5,4-B]Pyridine-4-Carboxylic Acid
CAS No.	878465-81-7
Molecular Formula	C16H9F3N2O3
Molecular Weight	334.25 g/mol
Synonyms	3-Methyl-6-[2-(trifluoromethyl)phenyl][1,2]oxazolo[5,4-b]pyridine-4-carboxylic acid; 3-Methyl-6-(2-(trifluoromethyl)phenyl)isoxazolo[5,4-b]pyridine-4-carboxylic acid; 878465-81-7; Isoxazolo[5,4-b]pyridine-4-carboxylic acid, 3-methyl-6-[2-(trifluoromethyl)phenyl]-; AX-8108; ZINC000103486773; BDBM50389385
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥95% (HPLC), suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. For cGMP or kilogram-scale production requirements, please contact our technical sales team to discuss custom synthesis and enhanced quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.