Description

(R)-tert-Butyl 5-Hydroxyisoxazolidine-2-Carboxylate is a high-value chiral building block and synthetic intermediate. This compound is critical for the stereoselective synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of new drug candidates, particularly in protease inhibitor and antibiotic research.
• Asymmetric Synthesis: Serves as a versatile precursor for introducing the isoxazolidine moiety with defined stereochemistry into target molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new bioactive compounds.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of chiral active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Intermediate in the production of advanced, stereochemically pure crop protection agents.
• Academic & Contract Research: Valuable reagent for methodological development in organic and medicinal chemistry laboratories.

Basic Information

Product Name	(R)-tert-Butyl 5-Hydroxyisoxazolidine-2-Carboxylate
CAS No.	878385-72-9
Molecular Formula	C8H15NO4
Molecular Weight	189.21 g/mol
Synonyms	(R)-5-Hydroxyisoxazolidine-2-carboxylic acid tert-butyl ester; tert-Butyl (5R)-5-hydroxy-1,2-oxazolidine-2-carboxylate; (R)-5-Hydroxy-2-isoxazolidinecarboxylic acid 1,1-dimethylethyl ester; (R)-N-Boc-5-hydroxyisoxazolidine; (R)-O-tert-Butyl 5-hydroxyisoxazolidine-2-carboxylate; Boc-(R)-5-hydroxyisoxazolidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 5-Hydroxyisoxazolidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.