Description

Methyl 2-Bromo-4,5-Difluorobenzoate is a high-purity fluorinated aromatic ester building block, essential for advanced organic synthesis. Its value lies in its precise molecular architecture, which serves as a critical intermediate for constructing complex molecules in regulated industries. This compound is primarily needed by research and development chemists and process scale-up teams within the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the bromo and difluoro substituents are leveraged for their biological activity and selectivity.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic cores in electronic and photonic materials, contributing to improved performance characteristics.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Functional Group Transformation: The methyl ester group can be hydrolyzed to the corresponding carboxylic acid or reduced to the aldehyde/alcohol, enabling further diversification of the molecular scaffold.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of tailored compounds for client-specific projects.

Basic Information

Product Name	Methyl 2-Bromo-4,5-Difluorobenzoate
CAS No.	878207-28-4
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	2-Bromo-4,5-difluorobenzoic acid methyl ester; Methyl 2-bromo-4,5-difluorobenzoate; Benzoic acid, 2-bromo-4,5-difluoro-, methyl ester; 4,5-Difluoro-2-bromobenzoic acid methyl ester; Methyl 4,5-difluoro-2-bromobenzoate; 2-Bromo-4,5-difluorobenzoic Acid Methyl Ester; Methyl α-bromo-4,5-difluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromo-4,5-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.