Description

2-Chloro-3-Cyano-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional heterocyclic building block that integrates a pyridine core with chloro, cyano, and pinacol boronate ester functionalities. This compound matters for its critical role in modern synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and advanced functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to construct novel heterocyclic scaffolds for crop protection agents and herbicides.
• Material Science Research: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group is specifically designed for palladium-catalyzed cross-coupling with aryl/heteroaryl halides, a cornerstone reaction in medicinal chemistry.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological processes.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in early-stage drug discovery.

Basic Information

Product Name	2-Chloro-3-Cyano-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridine
CAS No.	878194-94-6
Molecular Formula	C₁₂H₁₄BClN₂O₂
Molecular Weight	264.51 g/mol
Synonyms	2-Chloro-3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-3-cyanopyridine; 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile; 878194-94-6; Pyridine, 2-chloro-3-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic acid, B-[2-chloro-3-cyano-4-pyridinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Cyano-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridine undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive coupling reactions. Our quality management system is designed to guarantee batch-to-batch consistency and reliability. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity. Recommended storage temperature is 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.